The default that catches people is attachment storage. MantisBT can put uploaded files in the database or on disk, and the documented default is the database, so a year of screenshots, logs and crash dumps ends up inside MySQL and inside whatever database allowance the plan carries. Switch it to disk storage, then remember your backup now has to cover two things rather than one.
Uploads fail in confusing ways when the application limit, PHP's upload_max_filesize and post_max_size disagree with each other, so set all three deliberately. PHP version is selectable per package in the My365i control panel, which matters here: stable 2.28.4 still declares PHP 7.4 as its floor while the development branch has moved to 8.1, and 7.4 left security support years ago. Install on a current PHP 8 branch.
Email is the other one. Every report, note and status change can notify several watchers, and with queued sending switched off, a user's page load waits while those messages crawl out over SMTP. Turn the queue on and run send_emails.php from cron.
Skip this entirely if your developers already live in GitHub or GitLab. A second tracker means a second set of accounts and a second place to look, and Issues is already included.